2-(4-Fluorophenyl)-3-(pyridin-4-yl)4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine dihydrochloride → 2-(4-Fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine hydrochloride

HRID 2260538Notes

Reaction equation

HRID 2260538 reaction equation
[ClH:1].Cl.[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:18]([C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)=[C:13]3[NH:14][CH2:15][CH2:16][CH2:17][N:12]3[N:11]=2)=[CH:6][CH:5]=1>C(O)(C)C>[ClH:1].[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:18]([C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)=[C:13]3[NH:14][CH2:15][CH2:16][CH2:17][N:12]3[N:11]=2)=[CH:6][CH:5]=1

Participants

3

Reactant 1

HCID 1363784152-(4-Fluorophenyl)-3-(pyridin-4-yl)4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine dihydrochloride

Product 1

HCID 1363784182-(4-Fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine hydrochlorideYield 49.7%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

2-(4-Fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine dihydrochloride (183 mg) was dissolved in hot aqueous isopropyl alcohol solution (5.5 ml). The solution was cooled and the separated solid was collected, washed with isopropyl alcohol and dried to give 2-(4-fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine hydrochloride (82 mg).

Workup

  1. temperatureThe solution was cooled
  2. customthe separated solid was collected
  3. washwashed with isopropyl alcohol
  4. customdried

Sources & evidence

ORD record
ord-afab60dabc504faf824cc97b4909d7dc
Source dataset
uspto-grants-1995_12
Patent number
US05478827

Reaction notes

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