反应详情

Potassium tert-butoxide (30.0 g) was added to a solution (150 ml) of a cis- and trans- mixture of methyl 4-(1-acetamido-1-methylethyl)cyclohexanecarboxylate (30.8 g) in methanol and the mixture was refluxed under heating for 40 hours. After completion of the reaction, the residue obtained by concentration under reduced pressure was poured into ice water, neutralized with conc. hydrochloric acid and extracted with chloroform. The extract was washed with water, dried and concentrated under reduced pressure. The resultant crystals were recrystallized from methanol to give 24.5 g of methyl trans-4-(1-acetamido-1-methylethyl)cyclohexanecarboxylate.

1. temperaturethe mixture was refluxed
2. temperatureunder heating for 40 hours
3. customAfter completion of the reaction
4. customthe residue obtained by concentration under reduced pressure
5. extractionextracted with chloroform
6. washThe extract was washed with water
7. customdried
8. concentrationconcentrated under reduced pressure
9. customThe resultant crystals were recrystallized from methanol