2,4,6-Trimethoxyaniline → 2-Methyl-6,11-dihydro-dibenzo[b,e]oxepine-11-carboxylic acid (2,4,6-trimethoxy-phenyl)-amide

HRID 2260582Notes

Reaction equation

HRID 2260582 reaction equation
[CH3:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][CH2:7][C:8]3[CH:17]=[CH:16][CH:15]=[CH:14][C:9]=3[CH:10]([C:11](O)=[O:12])[C:4]=2[CH:3]=1.[CH3:20][O:21][C:22]1[CH:28]=[C:27]([O:29][CH3:30])[CH:26]=[C:25]([O:31][CH3:32])[C:23]=1[NH2:24]>>[CH3:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][CH2:7][C:8]3[CH:17]=[CH:16][CH:15]=[CH:14][C:9]=3[CH:10]([C:11]([NH:24][C:23]3[C:25]([O:31][CH3:32])=[CH:26][C:27]([O:29][CH3:30])=[CH:28][C:22]=3[O:21][CH3:20])=[O:12])[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 842712,4,6-TrimethoxyanilineHCID 101063426,11-Dihydro-2-methyldibenz[b,e]-oxepin-11-carboxylic acid

Product 1

HCID 102515042-Methyl-6,11-dihydro-dibenzo[b,e]oxepine-11-carboxylic acid (2,4,6-trimethoxy-phenyl)-amideYield 40.8%

Procedure

The similar procedures as in Example 1 were repeated except using 2.32 g of Compound A and 1.85 g of 2,4,6-trimethoxyaniline in place of aniline to obtain 1.56 g of Compound 10 as amorphous.

Sources & evidence

ORD record
ord-146c41e9e9ca4133b33ef2ff25291a5f
Source dataset
uspto-grants-1995_12
Patent number
US05478835

Reaction notes

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