2,6-Diethylaniline → Dibenz(b,e)oxepin-11-carboxamide, 6,11-dihydro-2-bromo-N-(2,6-diethylphenyl)-

HRID 2260586Notes

Reaction equation

HRID 2260586 reaction equation
[Br:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][CH2:7][C:8]3[CH:17]=[CH:16][CH:15]=[CH:14][C:9]=3[CH:10]([C:11]([OH:13])=O)[C:4]=2[CH:3]=1.[CH2:20]([C:22]1[CH:28]=[CH:27][CH:26]=[C:25]([CH2:29][CH3:30])[C:23]=1[NH2:24])[CH3:21]>>[Br:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][CH2:7][C:8]3[CH:17]=[CH:16][CH:15]=[CH:14][C:9]=3[CH:10]([C:11]([NH:24][C:23]3[C:25]([CH2:29][CH3:30])=[CH:26][CH:27]=[CH:28][C:22]=3[CH2:20][CH3:21])=[O:13])[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 113692,6-DiethylanilineHCID 104036412-Bromo-6,11-dihydrodibenz[b,e]oxepin-11-carboxylic acid

Product 1

HCID 3072814Dibenz(b,e)oxepin-11-carboxamide, 6,11-dihydro-2-bromo-N-(2,6-diethylphenyl)-Yield 64%

Procedure

The similar procedures as in Example 1 were repeated except using 1.37 g of Compound H obtained in Example 46 in place of Compound A and 0.59 g of 2,6-diethylaniline in place of aniline to obtain 1.14 g of Compound 27.

Sources & evidence

ORD record
ord-e448cdd0264e4cd7a76c64c54fd15140
Source dataset
uspto-grants-1995_12
Patent number
US05478835

Reaction notes

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