2,6-Dichloroaniline → 2-Bromo-N-(2,6-dichlorophenyl)-6,11-dihydrodibenz[b,e]oxepin-11-carboxamide

HRID 2260593Notes

Reaction equation

HRID 2260593 reaction equation
[Br:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][CH2:7][C:8]3[CH:17]=[CH:16][CH:15]=[CH:14][C:9]=3[CH:10]([C:11](O)=[O:12])[C:4]=2[CH:3]=1.[Cl:20][C:21]1[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[C:22]=1[NH2:23]>>[Br:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][CH2:7][C:8]3[CH:17]=[CH:16][CH:15]=[CH:14][C:9]=3[CH:10]([C:11]([NH:23][C:22]3[C:21]([Cl:20])=[CH:27][CH:26]=[CH:25][C:24]=3[Cl:28])=[O:12])[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 118462,6-DichloroanilineHCID 104036412-Bromo-6,11-dihydrodibenz[b,e]oxepin-11-carboxylic acid2×

Product 1

HCID 103671142-Bromo-N-(2,6-dichlorophenyl)-6,11-dihydrodibenz[b,e]oxepin-11-carboxamideYield 18.4%

Procedure

The similar procedures as in Example 1 were repeated except using 1.67 g of 2-bromo-6,11-dihydrodibenz[b,e]oxepin-11-carboxylic acid obtained in Example 46 (Compound H) in place of Compound A and 0.76 g of 2,6-dichloroaniline in place of aniline to obtain 0.40 g of Compound 39.

Sources & evidence

ORD record
ord-89037247c01541faa79f50124641ead4
Source dataset
uspto-grants-1995_12
Patent number
US05478835

Reaction notes

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