2,4-Difluoroaniline → 2-Bromo-N-(2,4-difluorophenyl)-6,11-dihydrodibenz[b,e]oxepin-11-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	2,4-Difluoroaniline	HCID 9709	—
Reactant	2-Bromo-6,11-dihydrodibenz[b,e]oxepin-11-carboxylic acid	HCID 10403641	—
Product	2-Bromo-N-(2,4-difluorophenyl)-6,11-dihydrodibenz[b,e]oxepin-11-carboxamide	HCID 10477765	47.5%

Reaction Steps

The similar procedures as in Example 1 were repeated except using 1.0 g of 2-bromo-6,11-dihydrodibenz[b,e]oxepin-11-carboxylic acid obtained in Example 46 (Compound H) in place of Compound A and 0.48 g of 2,4-difluoroaniline in place of aniline to obtain 0.64 g of Compound 40.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05478835
Source dataset	uspto-grants-1995_12
ORD ID	ord-3134d55c0fea41f5a2501d583c69784b
Source note	uspto-grants-1995_12