2,4-Difluoroaniline → 2-Bromo-N-(2,4-difluorophenyl)-6,11-dihydrodibenz[b,e]oxepin-11-carboxamide

HRID 2260594Notes

Reaction equation

HRID 2260594 reaction equation
[Br:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][CH2:7][C:8]3[CH:17]=[CH:16][CH:15]=[CH:14][C:9]=3[CH:10]([C:11](O)=[O:12])[C:4]=2[CH:3]=1.[F:20][C:21]1[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][C:22]=1[NH2:23]>>[Br:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][CH2:7][C:8]3[CH:17]=[CH:16][CH:15]=[CH:14][C:9]=3[CH:10]([C:11]([NH:23][C:22]3[CH:24]=[CH:25][C:26]([F:28])=[CH:27][C:21]=3[F:20])=[O:12])[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 97092,4-DifluoroanilineHCID 104036412-Bromo-6,11-dihydrodibenz[b,e]oxepin-11-carboxylic acid2×

Product 1

HCID 104777652-Bromo-N-(2,4-difluorophenyl)-6,11-dihydrodibenz[b,e]oxepin-11-carboxamideYield 47.5%

Procedure

The similar procedures as in Example 1 were repeated except using 1.0 g of 2-bromo-6,11-dihydrodibenz[b,e]oxepin-11-carboxylic acid obtained in Example 46 (Compound H) in place of Compound A and 0.48 g of 2,4-difluoroaniline in place of aniline to obtain 0.64 g of Compound 40.

Sources & evidence

ORD record
ord-3134d55c0fea41f5a2501d583c69784b
Source dataset
uspto-grants-1995_12
Patent number
US05478835

Reaction notes

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