Diisopropylaniline → HCID 18998506, compound

HRID 2260595Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:16][CH2:15][C:10]3=[N:11][CH:12]=[CH:13][CH:14]=[C:9]3[CH:8]([C:17]([OH:19])=O)[C:7]=2[CH:20]=1.[CH:21]([C:24]1[CH:30]=[CH:29][CH:28]=[C:27]([CH:31]([CH3:33])[CH3:32])[C:25]=1[NH2:26])([CH3:23])[CH3:22]>>[CH:31]([C:27]1[CH:28]=[CH:29][CH:30]=[C:24]([CH:21]([CH3:23])[CH3:22])[C:25]=1[NH:26][C:17]([CH:8]1[C:9]2[C:10](=[N:11][CH:12]=[CH:13][CH:14]=2)[CH2:15][O:16][C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:20][C:7]1=2)=[O:19])([CH3:33])[CH3:32]

Participants

Reactant 2

HCID 32484Diisopropylaniline

HCID 18998515HCID 18998515, compound2×

Product 1

HCID 18998506HCID 18998506, compoundYield 73.2%

Procedure

The similar procedures as in Example 1 were repeated except using 0.74 g of 5,11-dihydro-7-methoxybenzoxepino[3,4-b]pyridin-5-carboxylic acid obtained in Example 58 (Compound W) in place of Compound A and 0.72 g of 2,6-diisopropylaniline in place of aniline to obtain 0.86 g of Compound 41.

Sources & evidence

ORD record: ord-59c2e31ad7824d209053a28aa8c1b294
Source dataset: uspto-grants-1995_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05478835

Reaction notes

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