HCID 10703813, compound → HCID 131719231, compound

HRID 2260636Notes

Reaction equation

HRID 2260636 reaction equation
[F:1][C:2]1[CH:20]=[CH:19][C:5]2[C:6]([CH:9]3[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][OH:18])[CH2:11][CH2:10]3)=[N:7][O:8][C:4]=2[CH:3]=1.[CH3:21][N:22]([C:26]1[CH:31]=[CH:30][C:29]2[O:32][CH2:33][O:34][C:28]=2[CH:27]=1)[C:23]([Cl:25])=[O:24]>>[ClH:25].[F:1][C:2]1[CH:20]=[CH:19][C:5]2[C:6]([CH:9]3[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][O:18][C:23](=[O:24])[N:22]([CH3:21])[C:26]4[CH:31]=[CH:30][C:29]5[O:32][CH2:33][O:34][C:28]=5[CH:27]=4)[CH2:11][CH2:10]3)=[N:7][O:8][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 10703813HCID 10703813, compoundHCID 153849663-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)propan-1-ol

Product 1

HCID 131719231HCID 131719231, compoundYield 34.6%

Procedure

By following the procedure described in example 2B 3-(4-(6-fluoro -1,2-benzisoxazol-3-yl)piperidino)propanol (278 mg, 1 mmol) was reacted with N-methyl-N-(3,4-methylenedioxyphenyl)carbamoylchloride (240 mg, 1.12 mmol) to give 170 mg of the title compound. M.p. 126°-129° C.

Sources & evidence

ORD record
ord-57437141a9de4cd6b0befe9b0b0de902
Source dataset
uspto-grants-1995_12
Patent number
US05478845

Reaction notes

Loading…