Hexane → HCID 131719232, compound

HRID 2260639Notes

Reaction equation

HRID 2260639 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][OH:21])[CH2:14][CH2:13]3)=[N:7][N:8]2[CH3:11])=[CH:4][CH:3]=1.CCCCCC.[N:28]1([C:38]([Cl:40])=[O:39])[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH2:31][CH2:30][CH2:29]1>>[ClH:40].[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][O:21][C:38]([N:28]4[C:37]5[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=5)[CH2:31][CH2:30][CH2:29]4)=[O:39])[CH2:14][CH2:13]3)=[N:7][N:8]2[CH3:11])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 8058HexaneHCID 135910691,2,3,4-Tetrahydroquinoline-1-carbonyl chlorideHCID 189987994-(6-fluoro-1-methyl-1H-indazol-3-yl)-1-(3-hydroxypropyl)piperidine

Product 1

HCID 131719232HCID 131719232, compoundYield 9%

Procedure

Starting from 4-(6-fluoro-1-methyl-I H-indazol-3-yl)-1-(3-hydroxypropyl)piperidine (370 mg; 1.2 mmol), 3M N-butyl lithium in hexane (0.7 ml; 2.1 mmol) and 1,2,3,4-tetrahydroquinolin-1-carbonyl chloride (300 mg; 1.5 mmol) using the procedure described in example 7 was prepared 50 mg (9%) of the title compound.

Sources & evidence

ORD record
ord-31343d9265cc4db2b44015268aeeb1b4
Source dataset
uspto-grants-1995_12
Patent number
US05478845

Reaction notes

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