Hydrochloric Acid → HCID 67672760, compound

HRID 2260683Notes

Reaction equation

HRID 2260683 reaction equation
[CH2:1]([O:3][C:4](=[O:24])[CH:5]=[CH:6][C:7]1([CH3:23])[CH2:11][C:10]2[C:12]([CH3:22])=[C:13]([NH:18]C(=O)C)[C:14]([CH3:17])=[C:15]([CH3:16])[C:9]=2[O:8]1)C.[ClH:25]>CO>[ClH:25].[NH2:18][C:13]1[C:14]([CH3:17])=[C:15]([CH3:16])[C:9]2[O:8][C:7]([CH:6]=[CH:5][C:4]([O:3][CH3:1])=[O:24])([CH3:23])[CH2:11][C:10]=2[C:12]=1[CH3:22]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54379595HCID 54379595, compound

Product 1

HCID 67672760HCID 67672760, compoundYield 74.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-[5-Acetylamino-2,4,6,7-tetramethyl-2,3-dihydrobenzofuran-2-yl]acrylic acid ethyl ester (0.5 g, 1.58 mmol) was dissolved in methanol (5 ml). Conc. hydrochloric acid (5 ml) was added to the solution and the mixture was heated under reflux for 1 hour. The reaction mixture was cooled and the crystals precipitated were filtered. The crude crystals obtained were recrystallized from ethanol-isopropyl ether to obtain the desired compound (0.35 g, yield: 74.7% yield ), m.p. 225°-234 ° C. (dec.).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 1 hour
  3. temperatureThe reaction mixture was cooled
  4. customthe crystals precipitated
  5. filtrationwere filtered
  6. customThe crude crystals obtained
  7. customwere recrystallized from ethanol-isopropyl ether

Sources & evidence

ORD record
ord-d95bd4feb81d47a3a209b26845ef0b4b
Source dataset
uspto-grants-1995_12
Patent number
US05478844

Reaction notes

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