反应详情

温度

100 °C

382 mg of 3-Bromo-2-methyl-thieno[2,3-b]pyridine (1.67 mmol) is placed into the vial with 2.5 ml of Reiki Zn, suspension in THF (1.75 mmol) and capped and heated at 100° C. for 2 h. The excess Zinc is allowed to settle down and the solution is transferred to the vial containing 200 mg of 8-(1-ethyl-propyl)-3-iodo-2,6-dimethyl-imidazo[1,2-b]pyridazine (0.58 mmol) and 41 mg of PdCl2(pddf) (0.05 mmol) in 3 ml of dry THF. The vial is capped with a Teflon cap and heated at 80° C. for 2 days. The reaction mixture is quenched with sat. NH4Cl and extracted by CH2Cl2, dried over Na2SO4 and evaporated. The crude product is applied onto a silica-gel chromatography column (Hexane:AcOEt=8:1) to give 22 mg of the title compound. Yield 4%. mass spectrum (m/e): 365 (M+1).

1. customcapped
2. customcap
3. temperatureheated at 80° C. for 2 days
4. customThe reaction mixture is quenched with sat. NH4Cl
5. extractionextracted by CH2Cl2
6. dry with materialdried over Na2SO4
7. customevaporated