HCID 57111979, compound → HCID 18998903, compound

HRID 2260715Notes

Reaction equation

HRID 2260715 reaction equation
[C:1]1(=[O:21])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][N:2]1[CH2:10][CH2:11][O:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17][OH:18])=[CH:15][CH:14]=1>[O-2].[Mn+4].[O-2].ClCCl>[C:1]1(=[O:21])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][N:2]1[CH2:10][CH2:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([CH:17]=[O:18])=[CH:19][CH:20]=1

Participants

4

Reactant 1

HCID 57111979HCID 57111979, compound

Product 1

HCID 18998903HCID 18998903, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

A mixture of 4-[2-(2,3-dihydro-1H-isoindol-1-on-2-yl)-ethoxy]benzyl alcohol (2.97 g), manganese(IV) oxide (9.12 g) and dichloromethane (180 ml) was stirred for 3 hours at room temperature. The mixture was filtered through a Soxhlet thimble and the residue extracted with refluxing dichloromethane for 3 hours. The solvent was then evaporated to afford the title compound, mp 134°-135° C.

Workup

  1. filtrationThe mixture was filtered through a Soxhlet thimble
  2. extractionthe residue extracted with refluxing dichloromethane for 3 hours
  3. customThe solvent was then evaporated

Sources & evidence

ORD record
ord-9e001c0264494fd89df6f493026afce6
Source dataset
uspto-grants-1995_12
Patent number
US05478851

Reaction notes

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