Succinic Acid → L-Aspartic Acid

HRID 2260791Notes

Reaction equation

[C:1]([O-:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5].[NH4+:9].C(O)(=O)CCC(O)=O.[OH-].[Na+]>>[NH2:9][C@H:2]([C:1]([OH:8])=[O:7])[CH2:3][C:4]([OH:6])=[O:5]

Participants

Reactant 3

HCID 1110Succinic Acid

HCID 14798Sodium Hydroxide

HCID 1159344144742-89-4

Product 1

HCID 5960L-Aspartic Acid

Conditions

Temperature: 240 °C

Procedure

Monoammonium maleate (3.00 g of 94% wet salt, 0.0212 mole) and succinic acid (0,278 g, 0.0024 mole) were thoroughly mixed together and then were reacted as in Example 2 and 3 by heating in a convection oven at 230°240° C. for 40 minutes. A brittle, red-brown solid was obtained which weighed 2,204 g. Hydrolysis of this product with sodium hydroxide produced an aspartic acid copolymer having molecular weights by GPC of Mw 1717, Mn 1016, Mw/Mn 1.69.

Workup

customwere reacted as in Example 2 and 3
customA brittle, red-brown solid was obtained which

Sources & evidence

ORD record: ord-d5adc51e1fd94b418ebb59a4e40974dc
Source dataset: uspto-grants-1995_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05478919

Reaction notes

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