反应详情

100 ml of n-tetrabutyl tin, then 120 mg of [benzyl (chloro) bis(triphenyl phosphine)]palladium were added to a solution of 40 ml of phenyl acetyl chloride in 500 ml of tetrahydrofuran. The mixture was stirred for 15 hours at reflux, filtered on clarcel and evaporated to dryness. The residue was distilled at 65° C. to 68° C. under 0.5 mm of mercury and the main fraction was chromatographed on silica (eluant: hexane--ethyl acetate (9-1)) to obtain 27.5 g of the desired product.

1. temperatureat reflux
2. filtrationfiltered on clarcel
3. customevaporated to dryness
4. distillationThe residue was distilled at 65° C. to 68° C. under 0.5 mm of mercury
5. customthe main fraction was chromatographed on silica (eluant: hexane--ethyl acetate (9-1))