2-Imidazolidinone → 4-[6-(2-Oxo-1-imidazolidinyl)-3-pyridazinyl]benzonitrile

HRID 2260856Notes

Reaction equation

HRID 2260856 reaction equation
[NH:1]1[CH2:5][CH2:4][NH:3][C:2]1=[O:6].Cl[C:8]1[N:9]=[N:10][C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]#[N:21])=[CH:16][CH:15]=2)=[CH:12][CH:13]=1.C(Cl)Cl.CO>CS(C)=O>[C:20]([C:17]1[CH:18]=[CH:19][C:14]([C:11]2[N:10]=[N:9][C:8]([N:1]3[CH2:5][CH2:4][NH:3][C:2]3=[O:6])=[CH:13][CH:12]=2)=[CH:15][CH:16]=1)#[N:21]

Participants

5

Reactant 3

HCID 84532-ImidazolidinoneHCID 64052563-Chloro-6-(4-cyanophenyl)pyridazineHCID 21226129Dichloromethane methanol

Product 1

HCID 220987114-[6-(2-Oxo-1-imidazolidinyl)-3-pyridazinyl]benzonitrile

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Prepared from imidazolidin-2-one and 3-chloro-6-(4-cyano-phenyl)-pyridazine in dimethylsulphoxide Rf value: 0.30 (silica gel; methylene chloride/methanol=19:1)

Sources & evidence

ORD record
ord-4660995728b44a85acc0774538297c19
Source dataset
uspto-grants-1995_12
Patent number
US05478942

Reaction notes

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