反应详情

温度

120 °C

A mixture of 7-benzyl-4-methylamino-7H-pyrrolo[2,3-b]pyridine-5-carbaldehyde (400 mg, 1.5 mmol), (2-methyl-5-nitro-phenyl)-acetic acid methyl ester (350 mg, 1.67 mmol) and cesium carbonate (1.1 g, 3 mmol) in 5 ml anhydrous DMF is heated to 120° C. for 30 min. The reaction mixture is cooled down to room temperature. The reaction mixture is partitioned in water and ethyl acetate, extracted with ethyl acetate three times. The organic phase is combined and washed with brine, dried over Na2SO4. The crude product is purified by silica gel flash chromatography, eluted with 40% to 100% ethyl acetate in hexane to give the title compound as light yellow solid. MS m/z 426.2 (M+1).

1. temperatureThe reaction mixture is cooled down to room temperature
2. customThe reaction mixture is partitioned in water
3. extractionethyl acetate, extracted with ethyl acetate three times
4. washwashed with brine
5. dry with materialdried over Na2SO4
6. customThe crude product is purified by silica gel flash chromatography
7. washeluted with 40% to 100% ethyl acetate in hexane