(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine → HCID 11596637, compound

HRID 2261208Notes

Reaction equation

HRID 2261208 reaction equation
CO[C:3](=[O:13])[C:4]1[C:9]([F:10])=[CH:8][C:7]([OH:11])=[CH:6][C:5]=1[F:12].Cl.Cl[CH2:16][C:17]1[N:18]=[CH:19][S:20][CH:21]=1.[NH:22]1[CH2:26][CH2:25][CH2:24][C@H:23]1[CH2:27][N:28]1[CH2:32][CH2:31][CH2:30][CH2:29]1>>[F:10][C:9]1[CH:8]=[C:7]([O:11][CH2:16][C:17]2[N:18]=[CH:19][S:20][CH:21]=2)[CH:6]=[C:5]([F:12])[C:4]=1[C:3]([N:22]1[CH2:26][CH2:25][CH2:24][C@H:23]1[CH2:27][N:28]1[CH2:32][CH2:31][CH2:30][CH2:29]1)=[O:13]

Participants

4

Reactant 3

HCID 853152(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidineHCID 27632894-(Chloromethyl)-1,3-thiazole hydrochlorideHCID 22087431Methyl 2,6-difluoro-4-hydroxybenzoate

Product 1

HCID 11596637HCID 11596637, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedures D and E using 2,6-difluoro-4-hydroxy-benzoic acid methyl ester [CAS 194938-88-0], 4-(chloromethyl)thiazole hydrochloride [CAS 7709-58-2], and (S)(+)-1-(2-pyrrolidinylmethyl)pyrrolidine. MS (ES+) m/e 408.3

Sources & evidence

ORD record
ord-24a61740a7904dfbbfd856a162c8e37c
Source dataset
uspto-grants-2010_12
Patent number
US07846950B2

Reaction notes

Loading…