4-(Chloromethyl)-1,3-thiazole hydrochloride → HCID 11524615, compound

HRID 2261210Notes

Reaction equation

HRID 2261210 reaction equation
CO[C:3](=[O:13])[C:4]1[C:9]([F:10])=[CH:8][C:7]([OH:11])=[CH:6][C:5]=1[F:12].Cl.Cl[CH2:16][C:17]1[N:18]=[CH:19][S:20][CH:21]=1.[CH3:22][C@@H:23]1[CH2:27][CH2:26][CH2:25][N:24]1[CH2:28][C@@H:29]1[CH2:33][CH2:32][CH2:31][NH:30]1>>[F:10][C:9]1[CH:8]=[C:7]([O:11][CH2:16][C:17]2[N:18]=[CH:19][S:20][CH:21]=2)[CH:6]=[C:5]([F:12])[C:4]=1[C:3]([N:30]1[CH2:31][CH2:32][CH2:33][C@H:29]1[CH2:28][N:24]1[CH2:25][CH2:26][CH2:27][C@H:23]1[CH3:22])=[O:13]

Participants

4

Reactant 3

HCID 27632894-(Chloromethyl)-1,3-thiazole hydrochlorideHCID 22087431Methyl 2,6-difluoro-4-hydroxybenzoateHCID 46911921(R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine

Product 1

HCID 11524615HCID 11524615, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedures D and E using 2,6-difluoro-4-hydroxy-benzoic acid methyl ester [CAS 194938-88-0], 4-(chloromethyl)thiazole hydrochloride [CAS 7709-58-2], and 2-(R)-methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine. MS (ES+) m/e 422.2

Sources & evidence

ORD record
ord-3bd1d1e0f2e947318d16b19b2855023e
Source dataset
uspto-grants-2010_12
Patent number
US07846950B2

Reaction notes

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