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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2261210Generated: November 3, 2026

4-(Chloromethyl)-1,3-thiazole hydrochloride → HCID 11524615, compound

https://huagongshe.com/reaction/2261210

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Chloromethyl)-1,3-thiazole hydrochlorideHCID 2763289—
ReactantMethyl 2,6-difluoro-4-hydroxybenzoateHCID 22087431—
Reactant(R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidineHCID 46911921—
ProductHCID 11524615HCID 11524615—

Reaction Steps

The title compound is prepared in a manner substantially analogous to Procedures D and E using 2,6-difluoro-4-hydroxy-benzoic acid methyl ester [CAS 194938-88-0], 4-(chloromethyl)thiazole hydrochloride [CAS 7709-58-2], and 2-(R)-methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine. MS (ES+) m/e 422.2

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07846950B2
Source datasetuspto-grants-2010_12
ORD IDord-3bd1d1e0f2e947318d16b19b2855023e
Source noteuspto-grants-2010_12