(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine → HCID 11502294, compound

HRID 2261211Notes

Reaction equation

HRID 2261211 reaction equation
CO[C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][C:5]=1[F:11].Cl.Cl[CH2:15][C:16]1[N:17]=[C:18]([CH3:21])[S:19][CH:20]=1.[NH:22]1[CH2:26][CH2:25][CH2:24][C@H:23]1[CH2:27][N:28]1[CH2:32][CH2:31][CH2:30][CH2:29]1>>[F:11][C:5]1[CH:6]=[C:7]([O:10][CH2:15][C:16]2[N:17]=[C:18]([CH3:21])[S:19][CH:20]=2)[CH:8]=[CH:9][C:4]=1[C:3]([N:22]1[CH2:26][CH2:25][CH2:24][C@H:23]1[CH2:27][N:28]1[CH2:32][CH2:31][CH2:30][CH2:29]1)=[O:12]

Participants

4

Reactant 3

HCID 853152(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidineHCID 27342034-(Chloromethyl)-2-methyl-1,3-thiazole--hydrogen chloride (1/1)HCID 22463192Methyl 2-fluoro-4-hydroxybenzoate

Product 1

HCID 11502294HCID 11502294, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedures D and E using 2-fluoro-4-hydroxy-benzoic acid methyl ester [CAS 197507-22-5], 4-chloromethyl-2-methylthiazole hydrochloride [CAS 39238-07-8], and (S)(+)-1-(2-pyrrolidinylmethyl)pyrrolidine. MS (ES+) m/e 404.2

Sources & evidence

ORD record
ord-b81920d4681e4b73a9612ca5b9811b08
Source dataset
uspto-grants-2010_12
Patent number
US07846950B2

Reaction notes

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