5-(Bromomethyl)thiophene-2-carbonitrile → HCID 11697599, compound

HRID 2261216Notes

Reaction equation

HRID 2261216 reaction equation
CO[C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][C:5]=1[F:11].Br[CH2:14][C:15]1[S:19][C:18]([C:20]#[N:21])=[CH:17][CH:16]=1.[CH3:22][C@@H:23]1[CH2:27][CH2:26][CH2:25][N:24]1[CH2:28][C@@H:29]1[CH2:33][CH2:32][CH2:31][NH:30]1>>[F:11][C:5]1[CH:6]=[C:7]([CH:8]=[CH:9][C:4]=1[C:3]([N:30]1[CH2:31][CH2:32][CH2:33][C@H:29]1[CH2:28][N:24]1[CH2:25][CH2:26][CH2:27][C@H:23]1[CH3:22])=[O:12])[O:10][CH2:14][C:15]1[S:19][C:18]([C:20]#[N:21])=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 105600165-(Bromomethyl)thiophene-2-carbonitrileHCID 22463192Methyl 2-fluoro-4-hydroxybenzoateHCID 46911921(R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine

Product 1

HCID 11697599HCID 11697599, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedures D and E using 2-fluoro-4-hydroxy-benzoic acid methyl ester [CAS 197507-22-5], 5-bromomethyl-thiophene-2-carbonitrile [CAS 134135-41-4], and 2-(R)-methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine. MS (ES+) m/e 428.3

Sources & evidence

ORD record
ord-0b95d970eb3c48ce981ad54ffdee82e0
Source dataset
uspto-grants-2010_12
Patent number
US07846950B2

Reaction notes

Loading…