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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2261216Generated: November 3, 2026

5-(Bromomethyl)thiophene-2-carbonitrile → HCID 11697599, compound

https://huagongshe.com/reaction/2261216

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(Bromomethyl)thiophene-2-carbonitrileHCID 10560016—
ReactantMethyl 2-fluoro-4-hydroxybenzoateHCID 22463192—
Reactant(R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidineHCID 46911921—
ProductHCID 11697599HCID 11697599—

Reaction Steps

The title compound is prepared in a manner substantially analogous to Procedures D and E using 2-fluoro-4-hydroxy-benzoic acid methyl ester [CAS 197507-22-5], 5-bromomethyl-thiophene-2-carbonitrile [CAS 134135-41-4], and 2-(R)-methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine. MS (ES+) m/e 428.3

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07846950B2
Source datasetuspto-grants-2010_12
ORD IDord-0b95d970eb3c48ce981ad54ffdee82e0
Source noteuspto-grants-2010_12