4-(Chloromethyl)-2-methyl-1,3-thiazole--hydrogen chloride (1/1) → HCID 11661667, compound

HRID 2261217Notes

Reaction equation

HRID 2261217 reaction equation
CO[C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][C:5]=1[F:11].Cl.Cl[CH2:15][C:16]1[N:17]=[C:18]([CH3:21])[S:19][CH:20]=1.[CH3:22][C@@H:23]1[CH2:27][CH2:26][CH2:25][N:24]1[CH2:28][C@@H:29]1[CH2:33][CH2:32][CH2:31][NH:30]1>>[F:11][C:5]1[CH:6]=[C:7]([O:10][CH2:15][C:16]2[N:17]=[C:18]([CH3:21])[S:19][CH:20]=2)[CH:8]=[CH:9][C:4]=1[C:3]([N:30]1[CH2:31][CH2:32][CH2:33][C@H:29]1[CH2:28][N:24]1[CH2:25][CH2:26][CH2:27][C@H:23]1[CH3:22])=[O:12]

Participants

4

Reactant 3

HCID 27342034-(Chloromethyl)-2-methyl-1,3-thiazole--hydrogen chloride (1/1)HCID 22463192Methyl 2-fluoro-4-hydroxybenzoateHCID 46911921(R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine

Product 1

HCID 11661667HCID 11661667, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedures D and E using 2-fluoro-4-hydroxy-benzoic acid methyl ester [CAS 197507-22-5], 4-chloromethyl-2-methylthiazole hydrochloride [CAS 39238-07-8], and 2-(R)-methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine. MS (ES+) m/e 418.2

Sources & evidence

ORD record
ord-4a09f6778eef43389d463d5e059ab53f
Source dataset
uspto-grants-2010_12
Patent number
US07846950B2

Reaction notes

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