HRID2261219

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2794605

2-(bromomethyl)-5-(trifluoromethyl)furan

C6H4BrF3O

结构：C[C@@H]1CCCN1C[C@@H]1CCCN1C(=O)c1ccc(O)cc1F

HCID11960537

未命名化合物

PRODUCTS

生成物

HCID84468

Trifluoroacetate

C2F3O2-

结构：C[C@@H]1CCCN1C[C@@H]1CCCN1C(=O)c1ccc(OCc2ccc(C(F)(F)F)o2)cc1F.O=C(O)C(F)(F)F

HCID86617870

未命名化合物

PROCEDURE

实验过程

The title compound is prepared in a manner substantially analogous to Procedure C from (2-Fluoro-4-hydroxy-phenyl)-[2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-methanone and 2-(bromomethyl)-5-(trifluoromethyl)furan [CAS 17515-77-4]. The crude product is purified by reversed phase chromatography to provide the desired product as a trifluoroacetate salt. MS (ES+) m/e 455.3

WORKUP

后处理

customThe crude product is purified by reversed phase chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-605e6454da8547f988de736fce86e042
来源数据集: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07846950B2
来源说明: uspto-grants-2010_12

反应 SMILES

[F:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9]([N:11]1[CH2:15][CH2:14][CH2:13][C@H:12]1[CH2:16][N:17]1[CH2:21][CH2:20][CH2:19][C@H:18]1[CH3:22])=[O:10].Br[CH2:24][C:25]1[O:26][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:28][CH:29]=1>>[F:31][C:30]([F:33])([F:32])[C:27]([OH:8])=[O:26].[F:1][C:2]1[CH:7]=[C:6]([O:8][CH2:24][C:25]2[O:26][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:28][CH:29]=2)[CH:5]=[CH:4][C:3]=1[C:9]([N:11]1[CH2:15][CH2:14][CH2:13][C@H:12]1[CH2:16][N:17]1[CH2:21][CH2:20][CH2:19][C@H:18]1[CH3:22])=[O:10].[F:31][C:30]([F:33])([F:32])[C:27]([O-:8])=[O:26]