2-(Bromomethyl)-5-(trifluoromethyl)furan → Trifluoroacetate

Participants

Role	Name	HCID	Charge
Reactant	2-(Bromomethyl)-5-(trifluoromethyl)furan	HCID 2794605	—
Reactant	(2-Fluoro-4-hydroxy-phenyl)-[2-(S)(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-methanone	HCID 11960537	—
Product	Trifluoroacetate	HCID 84468	—
Product	[2-Fluoro-4-(5-trifluoromethyl-furan-2-ylmethoxy)-phenyl]-[2-(s)(2-(r)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-methanone trifluoroacetate salt	HCID 86617870	—

Reaction Steps

The title compound is prepared in a manner substantially analogous to Procedure C from (2-Fluoro-4-hydroxy-phenyl)-[2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-methanone and 2-(bromomethyl)-5-(trifluoromethyl)furan [CAS 17515-77-4]. The crude product is purified by reversed phase chromatography to provide the desired product as a trifluoroacetate salt. MS (ES+) m/e 455.3

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07846950B2
Source dataset	uspto-grants-2010_12
ORD ID	ord-605e6454da8547f988de736fce86e042
Source note	uspto-grants-2010_12