Thionyl Chloride → HCID 57736299, compound

HRID 2261289Notes

Reaction equation

HRID 2261289 reaction equation
[C:1]([C:5]1[CH:9]=[C:8]([CH2:10]O)[S:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].S(Cl)([Cl:14])=O>ClCCl>[C:1]([C:5]1[CH:9]=[C:8]([CH2:10][Cl:14])[S:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 57736297HCID 57736297, compound

Product 1

HCID 57736299HCID 57736299, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.61 g of (3-t-butyl-isothiazol-5-yl)methanol was dissolved in 50 ml of dichloromethane, and 3.2 ml of thionyl chloride was added. The mixture was stirred at room temperature for 5 hours. The reaction mixture was concentrated under reduced pressure to obtain 1.12 g of 3-t-butyl-5-(chloromethyl)isothiazole. The crude product was subjected to the next step without purification.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-1918d626f1464f8eb9f7dee318743db5
Source dataset
uspto-grants-2010_12
Patent number
US07846956B2

Reaction notes

Loading…