Thionyl Chloride → HCID 57736299, compound

Participants

Reaction Steps

1.61 g of (3-t-butyl-isothiazol-5-yl)methanol was dissolved in 50 ml of dichloromethane, and 3.2 ml of thionyl chloride was added. The mixture was stirred at room temperature for 5 hours. The reaction mixture was concentrated under reduced pressure to obtain 1.12 g of 3-t-butyl-5-(chloromethyl)isothiazole. The crude product was subjected to the next step without purification.

Provenance & Evidence