反应详情

1.83 g of ethyl 5-t-butyl-isoxazole-5-carboxylate was dissolved in 18 ml of tetrahydrofuran, and 0.70 g of sodium borohydride in 10 ml of ethanol was then added. The mixture was stirred at room temperature for 10 hours. After 5 ml of water was added, the reaction mixture was concentrated to 5 ml under reduced pressure. The concentrated solution was extracted with methyl-t-butyl ether. The organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure to obtain 0.62 g of (5-t-butyl-isoxazol-3-yl)methanol.

1. concentrationthe reaction mixture was concentrated to 5 ml under reduced pressure
2. extractionThe concentrated solution was extracted with methyl-t-butyl ether
3. dry with materialThe organic layer was dried over anhydrous sodium sulfate
4. concentrationconcentrated under reduced pressure