Thionyl Chloride → 1-tert-butyl-4-(chloromethyl)-1H-pyrazole hydrochloride

HRID 2261295Notes

Reaction equation

HRID 2261295 reaction equation
[C:1]([N:5]1[CH:9]=[C:8]([CH2:10]O)[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2].S(Cl)([Cl:14])=O>ClCCl>[ClH:14].[C:1]([N:5]1[CH:9]=[C:8]([CH2:10][Cl:14])[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 43753535(1-Tert-butyl-1h-pyrazol-4-yl)methanol

Product 1

HCID 687772531-tert-butyl-4-(chloromethyl)-1H-pyrazole hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.77 g of (1-t-butyl-1H-pyrazol-4-yl)methanol was dissolved in 25 ml of dichloromethane, and 1.7 ml of thionyl chloride was added. The mixture was stirred at room temperature for 5 hours. Thereafter, the reaction mixture was concentrated under reduced pressure to obtain 1.12 g of 1-t-butyl-4-(chloromethyl)-1H-pyrazole hydrochloride.

Workup

  1. concentrationThereafter, the reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-64e7146587fb49138242e87e772b9fa5
Source dataset
uspto-grants-2010_12
Patent number
US07846956B2

Reaction notes

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