Thionyl Chloride → 1-tert-butyl-4-(chloromethyl)-1H-pyrazole hydrochloride

Participants

Reaction Steps

0.77 g of (1-t-butyl-1H-pyrazol-4-yl)methanol was dissolved in 25 ml of dichloromethane, and 1.7 ml of thionyl chloride was added. The mixture was stirred at room temperature for 5 hours. Thereafter, the reaction mixture was concentrated under reduced pressure to obtain 1.12 g of 1-t-butyl-4-(chloromethyl)-1H-pyrazole hydrochloride.

Provenance & Evidence