Thionyl Chloride → 1-Benzyl-4-(chloromethyl)-1H-pyrazole--hydrogen chloride (1/1)

HRID 2261298Notes

Reaction equation

HRID 2261298 reaction equation
[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13]O)[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:17])=O>ClCCl>[ClH:17].[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13][Cl:17])[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 16769828(1-benzyl-1H-pyrazol-4-yl)methanol

Product 1

HCID 534223841-Benzyl-4-(chloromethyl)-1H-pyrazole--hydrogen chloride (1/1)

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.88 g of (1-benzyl-1H-pyrazol-4-yl)methanol was dissolved in 30 ml of dichloromethane, and 2.1 ml of thionyl chloride was added. The mixture was stirred at room temperature for 5 hours. The reaction mixture was concentrated under reduced pressure to obtain 2.39 g of 1-benzyl-4-(chloromethyl)-1H-pyrazole hydrochloride.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-4a99bdcd3ffa489d9110a75bc35c9670
Source dataset
uspto-grants-2010_12
Patent number
US07846956B2

Reaction notes

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