反应详情

温度

0 °C

In a nitrogen atmosphere, 0.30 g of ethyl 2-(2-propynyloxy)-1,3-thiazole-4-carboxylate was dissolved in 10 ml of tetrahydrofuran, and 3.3 ml of a solution (1 mol/L) of diisobutylaluminum hydride in toluene was added dropwise at 0° C. The mixture was stirred at 0° C. for 1 hour. The reaction mixture was added to aqueous saturated sodium chloride and then extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure to obtain 0.22 g of [2-(2-propynyloxy)-thiazol-4-yl]methanol.

1. extractionextracted with ethyl acetate
2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
3. concentrationconcentrated under reduced pressure