Thionyl Chloride → 1-cyclohexyl-4-(chloromethyl)-1H-pyrazole hydrochloride

HRID 2261317Notes

Reaction equation

HRID 2261317 reaction equation
[CH:1]1([N:7]2[CH:11]=[C:10]([CH2:12]O)[CH:9]=[N:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.S(Cl)([Cl:16])=O>ClCCl>[ClH:16].[CH:1]1([N:7]2[CH:11]=[C:10]([CH2:12][Cl:16])[CH:9]=[N:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 57736379(1-cyclohexyl-1H-pyrazol-4-yl)methanol

Product 1

HCID 687777401-cyclohexyl-4-(chloromethyl)-1H-pyrazole hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.68 g of (1-cyclohexyl-1H-pyrazol-4-yl)methanol was dissolved in 20 ml of dichloromethane, and 2.0 ml of thionyl chloride was then added. The mixture was stirred at room temperature for 5 hours. The reaction mixture was concentrated under reduced pressure to obtain 2.15 g of 1-cyclohexyl-4-(chloromethyl)-1H-pyrazole hydrochloride.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-728001e2b8f04767b2b31e542ca825ea
Source dataset
uspto-grants-2010_12
Patent number
US07846956B2

Reaction notes

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