[5-(Propan-2-yl)-1,2-oxazol-3-yl]methanol → 5-isopropylisoxazole-3-carbaldehyde
Reaction equation
[CH:1]([C:4]1[O:8][N:7]=[C:6]([CH2:9][OH:10])[CH:5]=1)([CH3:3])[CH3:2]>O1CCOCC1.[O-2].[O-2].[Mn+4]>[CH:1]([C:4]1[O:8][N:7]=[C:6]([CH:9]=[O:10])[CH:5]=1)([CH3:3])[CH3:2]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
7.59 g of (5-i-propyl-isoxazol-3-yl)methanol was dissolved in 100 ml of 1,4-dioxane, and 21.74 g of manganese dioxide was then added. The mixture was stirred and heated under reflux for 10 hours. The reaction mixture was cooled to room temperature and then filtered through Celite®. The filtrate was concentrated under reduced pressure to obtain 6.72 g of 5-i-propyl-isoxazole-3-carbaldehyde.
Workup
- temperatureheated
- temperatureunder reflux for 10 hours
- filtrationfiltered through Celite®
- concentrationThe filtrate was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-4bcacf6a2d234571bddd39f6c003316d
- Source dataset
- uspto-grants-2010_12
- Patent number
- US07846956B2
Reaction notes
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