Dichloromethane → HCID 73989418, compound

HRID 226134Notes

Reaction equation

HRID 226134 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:9][S:10]([C:13]2[CH:14]=[C:15]([CH:19]=[CH:20][C:21]([OH:23])=O)[CH:16]=[CH:17][CH:18]=2)(=[O:12])=[O:11])[CH:6]=[CH:7][CH:8]=1.[Cl:24]CCl>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:9][S:10]([C:13]2[CH:14]=[C:15]([CH:19]=[CH:20][C:21]([Cl:24])=[O:23])[CH:16]=[CH:17][CH:18]=2)(=[O:12])=[O:11])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 67019645HCID 67019645, compound

Product 1

HCID 73989418HCID 73989418, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideCatalyst

Conditions

Temperature
40 °C

Procedure

To a suspension of 3-[3-(3-methoxyphenyl-sulfamoyl)-phenyl]-acrylic acid (5i) (0.38 g, 1.14 mmol) in dichloromethane (4 ml) oxalyl chloride (0.3 ml, 3.43 mmol) and one drop of dimethylformamide were added. The reaction mixture was stirred at 40° C. for one hour and concentrated under reduced pressure to give crude title compound (0.40 g, 100%).

Workup

  1. additionwere added
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-7be5aba51d824c0684477bf88f313820
Source dataset
uspto-grants-2009_07
Patent number
US07557140B2

Reaction notes

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