Water → HCID 57736344, compound

HRID 2261343Notes

Reaction equation

HRID 2261343 reaction equation
[Si:1]([O:8][CH2:9][C:10]1[O:14][N:13]=[C:12]([CH2:15]O)[CH:11]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].C1(C)C=CC(S([Cl:26])(=O)=O)=CC=1.O>N1C=CC=CC=1>[Si:1]([O:8][CH2:9][C:10]1[O:14][N:13]=[C:12]([CH2:15][Cl:26])[CH:11]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 962WaterHCID 73974-Toluenesulfonyl chlorideHCID 57736305HCID 57736305, compound

Product 1

HCID 57736344HCID 57736344, compoundYield 22.3%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

18.64 g of [5-(t-butyldimethylsilanyloxymethyl)isoxazol-3-yl]methanol was dissolved in 80 ml of pyridine, and 16.06 g of 4-toluenesulfonyl chloride was then added under ice-cooling. The mixture was stirred for 10 hours under ice-cooling. After water was added, the reaction mixture was extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate, filtered and then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 4.48 g of 5-(t-butyldimethylsilanyloxymethyl)-3-(chloromethyl)isoxazole.

Workup

  1. temperaturecooling
  2. temperaturecooling
  3. extractionthe reaction mixture was extracted with ethyl acetate
  4. washThe organic layer was washed with water
  5. dry with materialdried over anhydrous magnesium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-aa45def689254ac089ae2d2403d9368d
Source dataset
uspto-grants-2010_12
Patent number
US07846956B2

Reaction notes

Loading…