Malononitrile → {[5-(1-Hydroxy-1-methylethyl)-isoxazol-3-yl]methylidene}malononitrile

HRID 2261352노트

반응식

HRID 2261352 반응식
[OH:1][C:2]([C:5]1[O:9][N:8]=[C:7]([CH:10]=O)[CH:6]=1)([CH3:4])[CH3:3].[C:12](#[N:16])[CH2:13][C:14]#[N:15]>C(O)C>[OH:1][C:2]([C:5]1[O:9][N:8]=[C:7]([CH:10]=[C:13]([C:12]#[N:16])[C:14]#[N:15])[CH:6]=1)([CH3:4])[CH3:3]

참가 물질

4

반응물 2

HCID 8010MalononitrileHCID 451179925-(2-Hydroxypropan-2-yl)isoxazole-3-carbaldehyde

생성물 1

HCID 57736335{[5-(1-Hydroxy-1-methylethyl)-isoxazol-3-yl]methylidene}malononitrile수율 88.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

4.63 g of 5-(1-hydroxy-1-methylethyl)isoxazole-3-carbaldehyde was dissolved in 50 ml of ethanol, and 1.98 g of malononitrile was then added. The mixture was stirred at room temperature for 5 hours. The reaction mixture was concentrated under reduced pressure, and the residue was subjected to silica gel column chromatography to obtain 5.35 g of {[5-(1-hydroxy-1-methylethyl)-isoxazol-3-yl]methylidene}malononitrile.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-fd1a20b82b624e7fa62561d8a9a8f982
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07846956B2

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