Water → 3-Methoxy-5-isoxazolemethanol

HRID 2261362노트

반응식

HRID 2261362 반응식
[CH3:1][O:2][C:3]1[CH:7]=[C:6]([C:8](OC)=[O:9])[O:5][N:4]=1.[BH4-].[Na+].O>C(O)C>[CH3:1][O:2][C:3]1[CH:7]=[C:6]([CH2:8][OH:9])[O:5][N:4]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 6392145-Isoxazolecarboxylic acid, 3-methoxy-, methyl esterHCID 4311764Sodium borohydride

생성물 1

HCID 106782583-Methoxy-5-isoxazolemethanol수율 84.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2.23 g of methyl 3-methoxyisoxazole-5-carboxylate was dissolved in 30 ml of ethanol, and 0.60 g of sodium borohydride was then added ice-cooling. The mixture was stirred for 8 hours under ice-cooling. After water was added under ice-cooling, the reaction mixture was concentrated under reduced pressure and then extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, filtered and then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 1.55 g of (3-methoxyisoxazol-5-yl)methanol.

후처리

  1. temperatureadded ice-cooling
  2. temperaturecooling
  3. temperaturecooling
  4. concentrationthe reaction mixture was concentrated under reduced pressure
  5. extractionextracted with ethyl acetate
  6. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  7. filtrationfiltered
  8. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a7c59a5f75694995bbb728f627f5e9a5
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07846956B2

반응 노트

불러오는 중…