HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 3-[1-(4-Acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 3-[1-(4-Acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl)-propionic acid methyl ester | HCID 57443428 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-[1-(4-Acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-propionic acid | HCID 11151229 | — |
Reaction Steps
3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-propionic acid methyl ester (i) prepared by above Step 2 of Example 18 dissolved in organic solvent such as tetrahydrofurane was reacted with LiOH to give 3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-propionic acid (k).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07846963B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-819764b7e41b4943a58bc0c22e5e7861 |
| Source note | uspto-grants-2010_12 |