Lithium Hydroxide → 3-[1-(4-Acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-propionic acid

HRID 2261397Notes

Reaction equation

HRID 2261397 reaction equation
C[O:2][C:3](=[O:24])[CH2:4][CH2:5][C:6]1[C:7](=[O:23])[N:8]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([NH:19][C:20](=[O:22])[CH3:21])=[CH:15][CH:14]=2)[CH2:9][CH2:10][CH:11]=1.[Li+].[OH-]>O1CCCC1>[C:20]([NH:19][C:16]1[CH:17]=[CH:18][C:13]([CH2:12][N:8]2[CH2:9][CH2:10][CH:11]=[C:6]([CH2:5][CH2:4][C:3]([OH:24])=[O:2])[C:7]2=[O:23])=[CH:14][CH:15]=1)(=[O:22])[CH3:21]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 574434283-[1-(4-Acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl)-propionic acid methyl ester

Product 1

HCID 111512293-[1-(4-Acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-propionic acid

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-propionic acid methyl ester (i) prepared by above Step 2 of Example 18 dissolved in organic solvent such as tetrahydrofurane was reacted with LiOH to give 3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-propionic acid (k).

Sources & evidence

ORD record
ord-819764b7e41b4943a58bc0c22e5e7861
Source dataset
uspto-grants-2010_12
Patent number
US07846963B2

Reaction notes

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