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HRID2261532

反应详情

EQUATION

反应方程式

HRID 2261532 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)C(=Cc1ccccc1)CC(=O)N1C[C@H]2CCCC[C@H]2C1
HCID54571848

未命名化合物

结构：O=C(Oc1ccccc1)N1C[C@@H](P(c2ccccc2)c2ccccc2)C[C@H]1CP(c1ccccc1)c1ccccc1
HCID86627672

未命名化合物

PRODUCTS

生成物

1
结构：O=C(O)[C@H](CC(=O)N1C[C@H]2CCCC[C@H]2C1)Cc1ccccc1
HCID121891

Mitiglinide

C19H25NO3

PROCEDURE

实验过程

The preparation was carried out in the same manner as in Example 1, except that 3.02 mg of (2S,4S)-N-phenyloxycarbonyl-4-diphenylphosphino-2-diphenylphosphinomethylpyrrolidine (PPPM) was used instead of 3.02 mg of PCPPM of Example 1. After the reaction, the residual ratio of 2-benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid was 9.74%, and the optical purity of mitiglinide thus obtained was 94.5% e.e.

WORKUP

后处理

  1. customAfter the reaction