HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid → Mitiglinide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid | HCID 54571848 | — |
| Reactant | (2S,4S)-N-phenyloxycarbonyl-4-diphenylphosphino-2-diphenylphosphinomethylpyrrolidine | HCID 86627672 | — |
| Product | Mitiglinide | HCID 121891 | — |
Reaction Steps
The preparation was carried out in the same manner as in Example 1, except that 3.02 mg of (2S,4S)-N-phenyloxycarbonyl-4-diphenylphosphino-2-diphenylphosphinomethylpyrrolidine (PPPM) was used instead of 3.02 mg of PCPPM of Example 1. After the reaction, the residual ratio of 2-benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid was 9.74%, and the optical purity of mitiglinide thus obtained was 94.5% e.e.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07847107B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-d9a9ed885def4d6aa0e19770fe17ec7f |
| Source note | uspto-grants-2010_12 |