Acetic Anhydride → HCID 49845771, compound

HRID 2261611Notes

Reaction equation

HRID 2261611 reaction equation
C([CH2:4][NH:5][C:6]1[N:14]=[CH:13][CH:12]=[CH:11][C:7]=1[C:8](O)=O)(O)=O.[C:15]([O-:18])(=[O:17])[CH3:16].[Na+].C(O[C:24](=[O:26])[CH3:25])(=O)C>>[C:24]([N:5]1[C:6]2=[N:14][CH:13]=[CH:12][CH:11]=[C:7]2[C:8]([O:17][C:15](=[O:18])[CH3:16])=[CH:4]1)(=[O:26])[CH3:25]

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 517045Sodium AcetateHCID 595933292-[(Carboxymethyl)amino]pyridine-3-carboxylic acid

Product 1

HCID 49845771HCID 49845771, compound

Procedure

Acetic acid 1-acetyl-1H-pyrrolo[2,3-b]pyridin-3-yl ester 502 is prepared by reacting 2-(Carboxymethyl-amino)-nicotinic acid 501 with sodium acetate in refluxing acetic anhydride for several hours, followed by purification and isolation by conventional means (e.g. recrystallization) (Su & Tsou; J. Am. Chem. Soc., 82, 1960, 1187).

Workup

  1. customfollowed by purification and isolation by conventional means (e.g. recrystallization) (Su & Tsou; J. Am. Chem. Soc., 82, 1960, 1187)

Sources & evidence

ORD record
ord-73710bc60cc84dd789cabd0251b18bc1
Source dataset
uspto-grants-2010_12
Patent number
US07846941B2

Reaction notes

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