Nitric Acid → HCID 178526747, compound

HRID 2261616Notes

Reaction equation

HRID 2261616 reaction equation
[NH:1]1[C:5]2=[N+:6]([O-:10])[CH:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[CH:2]1.S(=O)(=O)(O)O.O.[N+:17]([O-])([OH:19])=[O:18]>>[N+:17]([C:9]1[CH:8]=[CH:7][N+:6]([O-:10])=[C:5]2[NH:1][CH:2]=[CH:3][C:4]=12)([O-:19])=[O:18]

Participants

5

Reactant 4

HCID 944Nitric AcidHCID 962WaterHCID 1118Sulfuric AcidHCID 178526243HCID 178526243, compound

Product 1

HCID 178526747HCID 178526747, compound

Conditions

Temperature
70 °C

Procedure

4-Nitro-1H-pyrrolo[2,3-b]pyridine 7-oxide 508 is prepared by dissolving 1H-Pyrrolo[2,3-b]pyridine 7-oxide 507 in nitric acid, followed by the addition of sulfuric acid. Heating (e.g. 70° C.) for one hour, followed by pouring into water provides compound 508, which is isolated by filtration. (Schneller et. al., J. Org. Chem. 1980, 45:4045)

Workup

  1. custom4-Nitro-1H-pyrrolo[2,3-b]pyridine 7-oxide 508 is prepared

Sources & evidence

ORD record
ord-89e97935a07a4d999ed51654807ba43f
Source dataset
uspto-grants-2010_12
Patent number
US07846941B2

Reaction notes

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