Glycolic Acid → N-octylglycolamide

HRID 2261721Notes

Reaction equation

HRID 2261721 reaction equation
[C:1]([OH:5])(=O)[CH2:2][OH:3].[CH2:6]([NH2:14])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]>>[CH2:6]([NH:14][C:1](=[O:5])[CH2:2][OH:3])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]

Participants

3

Reactant 2

HCID 757Glycolic AcidHCID 8143Octylamine

Product 1

HCID 11074148N-octylglycolamide

Procedure

0.75 mol of glycolic acid were melted at 80° C., then 1.11 mol of octylamine were added dropwise with stirring. After the exothermic reaction had subsided, the mixture was heated for one hour to 165° C. and then the excess amine was distilled off under reduced pressure. The product was obtained after cooling in the form of a white, crystalline solid.

Workup

  1. customAfter the exothermic reaction
  2. temperaturethe mixture was heated for one hour to 165° C.
  3. distillationthe excess amine was distilled off under reduced pressure
  4. customThe product was obtained
  5. temperatureafter cooling in the form of a white, crystalline solid

Sources & evidence

ORD record
ord-05c7e8dc0c1e4e3997169b505196a552
Source dataset
uspto-grants-2010_12
Patent number
US07847123B2

Reaction notes

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