Dimethylformamide dimethyl acetal → HCID 66906104, compound

HRID 2261732Notes

Reaction equation

HRID 2261732 reaction equation
[CH2:1]([O:3][C:4](=[O:11])[C:5](=[O:10])[CH2:6][CH:7]1[CH2:9][CH2:8]1)[CH3:2].CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>>[CH2:1]([O:3][C:4](=[O:11])[C:5](=[O:10])[C:6]([CH:7]1[CH2:9][CH2:8]1)=[CH:14][N:15]([CH3:17])[CH3:16])[CH3:2]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 22285629Ethyl 3-cyclopropyl-2-oxopropanoate

Product 1

HCID 66906104HCID 66906104, compoundYield 102.1%

Procedure

A mixture of 3-cyclopropyl-2-oxo-propionic acid ethyl ester (6.4 mmol, 1.0 g) and dimethylformamide dimethylacetal (12.8 mmol, 2.0 mL) are combined and stirred at room temperature for 18 hours. The reaction is concentrated under reduced pressure to yield the title compound (1.38 g, 100%). LC-MS: 212.0 (M+1).

Workup

  1. concentrationThe reaction is concentrated under reduced pressure

Sources & evidence

ORD record
ord-1ef09ef83ef44ebf9abbe9cd62c34d74
Source dataset
uspto-grants-2010_12
Patent number
US07846960B2

Reaction notes

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