Pyridine → HCID 57754342, compound

HRID 226210Notes

Reaction equation

HRID 226210 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C@@H:8]([NH2:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.N1C=CC=CC=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>C1COCC1>[Br:1][C:2]1[CH:3]=[C:4]([C@@H:8]([NH:10][C:17](=[O:19])[CH3:18])[CH3:9])[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 9952938(S)-1-(3-bromophenyl)ethanamine

Product 1

HCID 57754342HCID 57754342, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Commercially available (S)-1-(3-bromophenyl)ethanamine (1.0 g, 5 mmol) was dissolved in THF (20 mL). Pyridine (0.5 mL) and acetic anhydride (0.51 g, 5 mmol) were added and the reaction mixture allowed to stir at room temperature overnight. The solvent was removed under reduced pressure to provide A4a.1 (1.23 g) as a clear yellowish liquid. (M+H)+=242.15, 244.16.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customto provide A4a.1 (1.23 g) as a clear yellowish liquid

Sources & evidence

ORD record
ord-f24aa6fc9ce94baa9c5291b423bc6c27
Source dataset
uspto-grants-2009_07
Patent number
US07557211B2

Reaction notes

Loading…