Hydrochloric Acid → HCID 57754027, compound

HRID 226214Notes

Reaction equation

HRID 226214 reaction equation
C(OC(=O)[NH:7][C@H:8]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([F:29])=[C:25]([F:30])[CH:24]=1)[C@@H:9]([OH:21])[CH2:10][NH:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=1)(C)(C)C.Cl>C(Cl)Cl.O1CCOCC1>[NH2:7][C@@H:8]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([F:29])=[C:25]([F:30])[CH:24]=1)[C@H:9]([OH:21])[CH2:10][NH:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68821139HCID 68821139, compound

Product 1

HCID 57754027HCID 57754027, compoundYield 109%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of (1R,2S)-[1-(3,4-Difluorobenzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-carbamic acid tert-butyl ester (0.04 g, 0.09 mmol) in methylene chloride (1 mL) was treated with 4 N HCl in dioxane (1 mL) at ambient temperature in one portion. The reaction was stirred for 12 hours and the solvent removed at reduced pressure to give the product as a solid (0.033 g, 98%). MS: 337 (M+H, 100%).

Workup

  1. customthe solvent removed at reduced pressure

Sources & evidence

ORD record
ord-b886c7ba30484897a486ee4103126019
Source dataset
uspto-grants-2009_07
Patent number
US07557137B2

Reaction notes

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