Hydrazine hydrate (1:1) → 3-amino-N,N-dimethylpropane-1-sulfonamide

HRID 2262269Notes

Reaction equation

HRID 2262269 reaction equation
[CH3:1][N:2]([CH3:20])[S:3]([CH2:6][CH2:7][CH2:8][N:9]1C(=O)C2C(=CC=CC=2)C1=O)(=[O:5])=[O:4].O.NN>C(O)C>[CH3:1][N:2]([CH3:20])[S:3]([CH2:6][CH2:7][CH2:8][NH2:9])(=[O:5])=[O:4]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 192616583-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propane-1-sulfonic acid dimethylamide

Product 1

HCID 192616433-amino-N,N-dimethylpropane-1-sulfonamide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propane-1-sulfonic acid dimethylamide (530 mg) in ethanol (10 mL) was added hydrazine monohydrate (0.80 mL) and the reaction was heated at reflux for 3 h. After cooling to room temperature, the mixture was filtered and the filtrate reduced in vacuo to give 3-amino-propane-1-sulfonic acid dimethylamide as a white solid.

Workup

  1. temperaturethe reaction was heated
  2. temperatureat reflux for 3 h
  3. filtrationthe mixture was filtered

Sources & evidence

ORD record
ord-9dab4b795adc4d77912d8742f07dcf7a
Source dataset
uspto-grants-2010_12
Patent number
US07846929B2

Reaction notes

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